Motilium alternatives: what to try when domperidone isn’t right for you

If Motilium (domperidone) isn’t available for you or you’re worried about its side effects, you’ve got options. The right choice depends on why you’re taking it — nausea, slow stomach emptying (gastroparesis), or reflux. Below I list common prescription swaps, non-drug fixes, and quick tips to help you decide what to ask your clinician about.

Prescription alternatives

Metoclopramide is the most common alternative. It helps stomach emptying and reduces nausea. It can cause drowsiness and, rarely, movement problems if used long term, so doctors usually limit dose and duration.

Ondansetron (Zofran) is a strong anti-nausea drug used after surgery or for chemotherapy. It doesn’t speed up the gut, but it’s effective for preventing or stopping vomiting. Ondansetron can affect heart rhythm in some people, so a check with your doctor is smart if you have heart issues or take other meds.

Promethazine and prochlorperazine are older antiemetics that work well for many causes of nausea. They can make you sleepy and are often used short-term.

Low-dose erythromycin acts as a prokinetic in some patients with gastroparesis, helping the stomach move food along. It’s not for long-term use because of tolerance and antibiotic concerns, but it can work short term under supervision.

Non-drug and lifestyle options

Small, frequent meals and low-fat, low-fiber choices make a big difference for folks with slow emptying. Sitting upright after eating, avoiding heavy meals before bed, and chewing food well helps too.

Ginger (tea, capsules, or candied) can reduce nausea for many people. Vitamin B6 (pyridoxine) is often recommended for pregnancy-related nausea and is low-risk at standard doses. Acupressure at the P6 point on the inner wrist can give relief for motion sickness or mild nausea.

Hydration and electrolyte balance matter. Sip clear fluids if full meals trigger nausea. Carbonated drinks in small amounts sometimes settle the stomach for a bit.

Always tell your doctor about heart disease, QT prolongation, or medications that affect the heart. Some alternatives also carry heart or neurologic risks, so a quick ECG or medication review may be needed.

If you’re trying to choose: match the treatment to the cause. Use prokinetics for gastroparesis, antiemetics for severe vomiting, and lifestyle or natural measures for mild or situational nausea. Don’t start or stop prescription meds without talking to a clinician. If you buy medicines online, use a reputable pharmacy and a valid prescription.

Got persistent symptoms? Ask your doctor for testing and a tailored plan. Nausea that won’t quit deserves proper evaluation so you get the safest, most effective option for you.