Furosemide alternatives: what to try when furosemide isn’t right

Furosemide (Lasix) is a strong loop diuretic many doctors use for fluid buildup. But it can cause low potassium, dehydration, ringing in the ears, or make you run to the bathroom all day. If you're asking "What else can I take?" this page breaks down safe, practical alternatives and what to watch for.

Drug alternatives that doctors often choose

Not every alternative works the same. Here are common options and why a doctor might pick each:

Other loop diuretics: Bumetanide and torsemide act like furosemide but differ in strength and how long they last. Torsemide has better oral absorption and a longer effect, so some patients get steadier control with fewer doses.

Thiazide diuretics: Hydrochlorothiazide, chlorthalidone, and indapamide are weaker than loop diuretics and work best for mild to moderate fluid retention or high blood pressure. Chlorthalidone often controls blood pressure longer than hydrochlorothiazide.

Potassium‑sparing diuretics: Spironolactone, eplerenone, amiloride, and triamterene help retain potassium. Spironolactone is common in heart failure and liver cirrhosis when you need to avoid low potassium. Watch for high potassium if used with ACE inhibitors or ARBs.

Combination therapy: Sometimes a low-dose loop plus a thiazide or a potassium-sparing drug gives the best balance between effect and side effects. Doctors tailor combos based on your condition and lab results.

Non-drug options & safety tips

Medications aren’t the only answer. Cutting salt, limiting fluids, losing a little weight, and wearing compression stockings can reduce swelling. For heart or liver-related fluid buildup, treating the underlying disease changes how well any diuretic works.

Labs matter: expect regular blood tests for electrolytes and kidney function when switching diuretics. Take diuretics in the morning to avoid nighttime urination. Avoid NSAIDs like ibuprofen—they can blunt diuretic effects. Tell your doctor about supplements, especially potassium or herbal remedies.

Thinking about switching? Talk to your prescriber first. They’ll choose the right drug, dose, and monitoring plan based on why you need a diuretic, other medicines you take, and your lab results. If you notice dizziness, muscle cramps, palpitations, sudden swelling, or excessive thirst after a change—call your provider right away.

Want help comparing options for a specific condition—like heart failure, kidney disease, or high blood pressure? Ask your clinician for a clear plan and a schedule for blood tests. A careful switch often improves symptoms and cuts side effects without losing control of fluid or blood pressure.